RetroSense Therapeutics Receives Patent on Proprietary Method for Restoring Vision using Optogenetics

RetroSense Therapeutics, a privately-held, clinical-stage biopharmaceutical company, announced that the United States Patent and Trademark Office (USPTO) has granted U.S. patent Application No. 11/036,629, entitled “Method for Augmenting Vision in Persons Suffering from Photoreceptor Cell Degeneration.” RetroSense is the exclusive licensee of this intellectual property for augmenting vision from photoreceptor cell degeneration through a license with Massachusetts General Hospital. This patent broadly covers methods for restoring or improving vision using optogenetic approaches. The allowed claims cover the use of a broad range of opsins and rhodopsins in vision restoration.

RetroSense Therapeutics is developing lead product RST-001 as a first-in-class gene therapy application of optogenetics designed to restore vision in patients suffering from blindness due to retinitis pigmentosa (RP) and advanced dry age-related macular degeneration. In March 2016, RetroSense announced that the first patient was successfully dosed in the first clinical trial to evaluate the safety of RST-001. There are currently no FDA approved drugs to improve or restore vision in patients with these retinal degenerative conditions.

“This is an important milestone in the quest to develop a therapy to restore or improve vision for patients suffering from retinitis pigmentosa or advanced dry age-related macular degeneration,” said Richard H. Masland, Ph.D., the first named inventor and David G. Cogan Professor of Ophthalmology at Massachusetts Eye and Ear Infirmary.

“The notice of allowance for this key patent complements our existing “Pan” patent portfolio which focuses on optogenetic gene therapies and complementary devices for vision restoration,” said Sean Ainsworth, CEO of RetroSense Therapeutics. “Expanding our patent portfolio is an important part of our strategy and the Masland patent improves our ability to develop and commercialize optogenetics.”

Optogenetics refers broadly to means of conferring light sensitivity to cells that were not previously, or natively light sensitive. By applying optogenetics to retinas in which rod and cone photoreceptors have degenerated, RetroSense is conferring new light sensitivity to the retina, with the expectation of improved or restored vision.

The Company's approach to using optogenetics in vision restoration is based on pioneering, proprietary research conducted by Dr. Zhuo-Hua Pan and others at Wayne State University’s Kresge Eye Institute and Department of Anatomy and Cell Biology, and Dr. Masland’s team at Massachusetts Eye and Ear Infirmary. RetroSense has worldwide exclusive rights to the relevant intellectual property from both institutions.

Disclaimers of Warranties
1. The website does not warrant the following:
1.1 The services from the website meets your requirement;
1.2 The accuracy, completeness, or timeliness of the service;
1.3 The accuracy, reliability of conclusions drawn from using the service;
1.4 The accuracy, completeness, or timeliness, or security of any information that you download from the website
2. The services provided by the website is intended for your reference only. The website shall be not be responsible for investment decisions, damages, or other losses resulting from use of the website or the information contained therein<
Proprietary Rights
You may not reproduce, modify, create derivative works from, display, perform, publish, distribute, disseminate, broadcast or circulate to any third party, any materials contained on the services without the express prior written consent of the website or its legal owner.

Tokushima, Japan – 17 June 2022: Nichia, the world’s largest LED manufacturer and inventor of high-brightness blue and white LEDs, announces the addition of the Direct Mountable Chip Series (Part Number: NVSWE21A-V1) to the portfol... READ MORE

DURHAM, N.C.--(BUSINESS WIRE)--Cree LED, an SGH company (Nasdaq: SGH), announced today the launch of XLamp® Element G LEDs, delivering a new product class with unmatched light output and efficiency for LEDs of this size. The... READ MORE